Metabology Crospovidone EP, 1000 Grams

Crospovidone EP is a cross-linked polyvinylpyrrolidone functioning as a superdisintegrant in tablets and capsules. Its highly porous structure and wicking capacity promote rapid water uptake and tablet breakup, supporting fast disintegration across direct-compression and wet-granulated systems. Unlike linear PVP, crospovidone is insoluble, maintaining particulate integrity during use. Particle size and bulk density are controlled to ensure uniform blending and content uniformity, even at low inclusion levels. It is compatible with many actives and excipients; formulators should assess interactions with oxidizers or reactive species. Typical applications include immediate-release cores, orodispersible tablets, and capsules requiring rapid dispersion. EP alignment provides recognized quality parameters for identity and limits. Store dry to preserve performance; optimize lubricant levels to avoid hydrophobic films that could slow water penetration.

Crospovidone EP