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Akuamma Seeds (Picralima Nitida) | 0.3%+ Akuammine – Seeds, 100g
Akuamma seeds contain a complex mixture of alkaloids producing potentially antipyretic and antiinflammatory effects along with analgesia. Several of these were shown to bind to opioid receptors in vitro, and two compounds, akuammidine and ψ-akuammigine, were found to be μ-opioid agonists. More recently, it has been shown that an additional constitutive analog, acuammicine, has potent activity as a kappa opioid receptor agonist.
Picralima nitida, the akuamma, is a tree. The dried seeds from this plant are used in traditional medicine throughout West Africa, particularly in Ghana as well as in the Ivory Coast and Nigeria. The seeds are crushed or powdered and taken orally, and are mainly used for the treatment of malaria, and diarrhea, and as a painkiller. The plant produces the alkaloids pericine and akuammine, among others.